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Nicotine receptor stimulation promotes wake time and reduces both total sleep time and rapid eye movement sleep." [7] Effects of nicotine diagram [edit] Comparative risk assessment chart [edit] Addiction and dependence [edit] Psychological and physical dependence [edit] Nicotine, a key ingredient [35] in most e-liquids, [36] is well-recognized as one of the most addictive substances, as addictive as heroin and cocaine

1929) with a portrait of Sir James Dewar FRS FRSE (18421923) and an illustration of liquid air

Byrne et al

However, other characteristics, such as size, shape or how the device functions may still allow it to imitate other products